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Modulon

Brand name: Modulon

Generic name: Trimebutine maleate

Preparations: tablets, parenteral (intramuscular injection)

Uses for IBS:
Modulon (trimebutine) is an antispasmodic agent with some affinity for opiate receptors and significant anti-serotonin activity. Serotonin is a neurotransmitter stored in the CNS but it is mostly (90-95%) stored in the gut. When activated, they can stimulate intestinal smooth muscle contraction, causing painful cramps. Modulon works against serotonin on “mu” receptors which are responsible for many things, among them, pain relief. In animal models, Modulon has shown the ability to coordinate electrophysiological spikes and contractions, which are important factors in regulating irregular intestinal motility. It works by decreasing bowel motility. This relieves the symptoms of spastic colon often seen with irritable bowel syndrome. Modulon is also commonly used after surgery when the patient has the condition paralytic ileus, where the bowels are not functional. It helps speed up the resumption of intestinal activity.

Contraindications:
At this time, only known hypersensitivities to trimebutine maleate are contraindicated. It is also not appropriate to administer injections to neonates. Although animal studies have not demonstrated birth defects, it is not considered safe to use trimebutine during pregnancy. Children under the age of 12 should not be given Modulon.

Special precaution should be taken when Modulon is used with any drug containing tubocurarine. Tubocurarine is a non-depolarizing (competitive) neuromuscular blocker often used in anesthesia for its ability to cause paralysis of muscles.

Adverse effects
The most frequently reported adverse effects involve the gastrointestinal system, CNS, and allergic reactions. These adverse reactions include dry mouth, foul taste, abdominal discomfort and pain, drowsiness, headaches, and rarely, rash.